Msalato Girls Secondary School started on January 1962 at Mvumi area. The school shifted from Mvumi area to Msalato area on 02nd Feb 1962. Msalato Secondary School has excellent academic performance. As far as creativity is concerned, Msalato students are innovative and have talents in various things. Some have artistic instincts such as singing, dancing, drawing, and designing. The school has been supportive as they have fixed a school's "talents day" and school "Bonanzas" in the school calendar to support and enhance the talents of these students.